Umeken BPx (Bidens Pilosa Extract)

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BPx - Allergy and Sinus Cure

The Best Kept Secret

In 1929, Alexander Fleming discovered Penicillin. It began to be readily available with WWII. At that time new antibiotics were being discovered daily. However, Dr. Fleming noted as early as 1929 that numerous bacteria were already resistant to Penicillin. At that time 14 percent of staph bacteria were resistant to penicillin. By 1995, with decades of wide spread use of antibiotics, 95% of staph were resistant to penicillin. In 1960, when resistant staph had become the most common hospital acquired infection, physicians started using methicillin to combat resistant strains. In just a year, MRSA (methicillin resistant staph) emerged. 70 years from the introduction to antibiotics, some staph bacteria have become resistant to all known pharmaceutical antibiotics. Bacteria seem to be winning the “war on disease.”

Herbs are different than pharmaceuticals. Bacteria can develop immunity to pharmaceuticals because they represent only one or a few compounds. Natural herbs on the other hand, are made up of hundreds of complex compounds that bacteria can’t develop immunity to. Bidens is a natural antibiotic that will successfully treat antibiotic resistant bacteria. It out performs penicillin, tetracycline, methicillin, and other antibiotics for both gram-positive and gram-negative bacteria.

“Bidens may be our best herb for benign prostrate hypertrophy, usually decreasing the membrane irritability both in the urinary tract and the rectum, and often, over a few weeks of use, noticeably shrinking the prostate and giving its connective tissue better tone.” (Michael Moore, Medicinal Plants of the Pacific West, p.71.)

In the last 20 years, we have worked with Mr. Komoto Masahiko, who is the Vice-President of The Society of Cosmetic Chemists of Japan as well as a renowned scientist and botanist. What he learned from the islanders on Okinawa Island was their longevity and their immunity. They swore to the “curing” herbal effects of the Biden pilosa which grew on the harsh volcanic outcrops of the Okinawa Islands and their ability to withstand the harsh elements.

It was from these initial observations that Mr. Masahiko embarked on a clinical and medical study on the type of Biden Pilosa that grew on the islands. After over 20 years of research and millions spent on cultivating on our Organic farms on Miyako island in Okinawa, BPx was derived and perhaps is the only viable form of Clinically proven Biden Pilosa extract to date! Here are some of the results and benefits this incredible plant has to offer.


Inflammation is at the root of many diseases, so given B. pilosa's wide use in folk medicine for a variety of illnesses, it is not surprising that studies are uncovering its anti-inflammatory properties. Research is now revealing modulation of various inflammatory cytokines which activate cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Ethyl caffeate, a phenolic compound isolated from B. pilosa, was studied using mouse skin and in vitro cell lines, and found to markedly suppress several of these cytokines, with significant inhibition of COX-2 expression. The production of PGE2, a growth promoting factor in certain carcinoma cell lines and a mediator of inflammation was also significantly inhibited by ethyl caffeate in this study.

Another study used normal human dermal fibroblasts to examine the effect of B. pilosa Linn. var radiata (aerial parts) following induction of inflammation. B. pilosa was found to suppress COX-2 expression and PGE2 production.

“Because it is a mucus membrane tonic and is astringent, powerfully anti-inflammatory, and strongly antibacterial, it is specific for a number of diseases caused by resistant pathogens: UTIs, chronic diarrhea and dysentery, gastritis and ulcers (anywhere in the GI tract, from mouth to anus), inflamed mucous membranes in colds and flu and respiratory infections of any sort, sore throats from coughs or infection or even overuse of the throat, and vaginal infections.” (Stephen Harrod Buhner, Herbal Antibiotics, Natural Alternatives for treating drug-resistant bacteria, p.137)


Many allergies occur through an inflammatory pathway, BPx TM was created to address the nasal allergy market. It has been shown to stabilise mast cells and basophils, decrease leukotriene synthesis and reduce the release of histamine and other mediators.


Diabetes is one disease where B. pilosa is one of many plants that has been used as a folk remedy in many parts of the world. A survey of plants traditionally used in Trinidad and Tobago found that B. pilosa and Bidens alba were both commonly used in the management of hypertension and diabetes.

There is good evidence for continuing research on B. pilosa in the prevention and management of diabetes, both types I and II. A murine study published in 2000 found two polyacetylenic glucosides derived from the aerial parts of B. pilosa, and administered in combination in a 3:2 ratio was shown to have a significant hypoglycaemic effect.

In another study of its hypoglycaemic effects, a test of normal mice against experimental alloxan-diabetic mice (one group mild, the other severe) using a water ethanol extract of B. pilosa (whole plant) showed significant hypoglycaemic results in the normal and mildly diabetic mice, but no change in the severely diabetic group. The authors suggest that insulin in the body is required as a mediator for the hypoglycaemic effects of the plant extract.

Cytopiloyne (a polyacetylenic glucoside) has been found to prevent type I diabetes in non-obese diabetic mice (NOD), through modulation of T cells. Specifically, it has been found to inhibit CD4+ T cells in the spleen and pancreatic lymph nodes of the NOD mice, leaving CD8+ T cells untouched. It also suppresses differentiation of Type 1 Th cells, and promotes production of Type 2 Th cells. Some in vitro experimentation with these cell lines was carried out, which showed less promising results than the in vivo experiments. The authors note that cytopiloyne works through a different mechanism than pharmaceutical drugs for type I diabetes prevention, is far less toxic, and less suppressive of the immune system.

Antimicrobial Action

B. pilosa has been found to have potent antimicrobial effects, including antiviral activity against types I and II herpes simplex (HSV) viruses. In vitro experiments using hot water extracts of the herb showed significant, dose-dependent effects against HSV. Measured against Acyclovir, B. pilosa at 500 mcg/mL performed equally against HSV2. Against HSV1, B. pilosa was more efficacious than against HSV2, but not quite as potent as Acyclovir. This is welcome, as the authors say that quite high dosages of the plant extract are well tolerated by human cells. Acyclovir, on the other hand, can have significant side effects including gastrointestinal upset, headache, vertigo, arthralgia, neurological reactions including convulsions, fatigue, fever, pruritus and other symptoms.

An in vitro study of ten medicinal plants used in Colombian folk medicine, which included B. pilosa, showed that this herb was active against several strains of bacteria including Bacillus cereus and Escherichia coli, outstripping the performance of Gentamycin sulfate. It was also active against Staphylococcus aureus.

Much of the research into the possible medical applications of Bidens pilosa has focused on the pharmacological activity of just a few of its chemical constituents. Bidens pilosa is rich in a class of anti-pathogenic chemicals know as the polyacetylenes. Among these is phenylheptatriyne, which in some studies has been found to inhibit cytomegalovirus as well as gram-positive bacteria in general. Aliphatic acetylenes has been found to inhibit the growth of Plasmodium falciparum, the microbe responsible for malaria infections. Although phenyheptatriyne and the other polyacetylenes are believed to be photoactivated, they have not been found to cause damage to genetic material like the photoactivated furanocoumarin toxins.

The flavonoids present in Bidens pilos have also shown some promise as anti-inflammatory agents. This activity is thought to be mediated through their interference with prostaglandin-synthesis, likely through the inhibition of cyclooxygenase (COX) enzymes. Friedelin and friedelan-3 beta-ol are the plant's most potent anti-inflammatory flavonoids, while phenylheptatriyne is the most effective of its polyacetylenes.

Whole plant extracts of Bidens pilosa have also been found to exhibit strong antioxidant and liver protecting properties. The same extract has been found to lower blood pressure in rats, potentially through its vasodilating activity. A similar animal study also found that rats given Bidens pilosa had lower levels of blood platelet aggretation and a reduced risk of thrombosis.

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